Enhanced transient receptor potential channel-mediated Ca2+influx in the cells with phospholipase C-δ1 overexpression: its possible role in coronary artery spasm
Volume: 31, Issue: 4, Pages: 383 - 391
Published: Feb 16, 2017
Abstract
We reported that coronary spasm was induced in the transgenic mice with the increased phospholipase C ( PLC )‐δ1 activity. We investigated the effect of enhanced PLC ‐δ1 on Ca 2+ influx and its underlying mechanisms. We used human embryonic kidney ( HEK )‐293 and coronary arteries smooth muscle cells ( CASMC ). Intracellular free Ca 2+ concentration ([Ca 2+ ] i ; n m ) was measured by fura‐2, and Ca 2+ influx was evaluated by the increase in [Ca...
Paper Details
Title
Enhanced transient receptor potential channel-mediated Ca2+influx in the cells with phospholipase C-δ1 overexpression: its possible role in coronary artery spasm
Published Date
Feb 16, 2017
Volume
31
Issue
4
Pages
383 - 391
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