Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion
Abstract
Mutations in mtDNA lead to muscular and neurological diseases and are linked to aging. The most frequent aberrancy is the “common deletion” that involves a 4,977-bp region flanked by 13-bp repeats. To investigate the basis of this deletion, we developed a single-molecule mtDNA combing method. The analysis of replicating mtDNA molecules provided in vivo evidence in support of the asymmetric mode of replication. Furthermore, we observed frequent...
Paper Details
Title
Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion
Published Date
Feb 1, 2017
Journal
Volume
65
Issue
3
Pages
527 - 538.e6
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