Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways
Abstract
Detection of evolutionarily conserved molecules on microbial pathogens by host immune sensors represents the initial trigger of the immune response against infection. Cytosolic receptors sense viral and intracellular bacterial genomes, as well as nucleic acids produced during replication. Once activated, these sensors trigger multiple signaling cascades, converging on the production of type I interferons and proinflammatory cytokines. Although...
Paper Details
Title
Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways
Published Date
Jan 8, 2017
Journal
Volume
38
Issue
3
Pages
194 - 205
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