The role and regulation of the peroxisome proliferator activated receptor alpha in human liver
Abstract
The peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor that is abundantly expressed in liver. PPARα is activated by fatty acids and various other lipid species, as well as by a class of chemicals referred to as peroxisome proliferators. Studies in mice have shown that PPARα serves as the master regulator of hepatic lipid metabolism during fasting. In addition, PPARα suppresses inflammation and the...
Paper Details
Title
The role and regulation of the peroxisome proliferator activated receptor alpha in human liver
Published Date
May 1, 2017
Journal
Volume
136
Pages
75 - 84
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