A copper‐catalyzed remote C−H amination of 8‐aminoquinoline scaffolds on the C5 position is described. The protocol employs commercially available N ‐fluorobenzenesulfonimide (NFSI) as the amination reagent and shows broad substrate scope, providing various 5‐aminated quinolines in moderate to excellent yields under mild conditions. These reactions feature complete regioselectivity, operational simplicity, and high efficiency. magnified image