Copper-Catalyzed Remote C−H Amination of Quinolines withN-Fluorobenzenesulfonimide

A copper-catalyzed remote C−H amination of 8-aminoquinoline scaffolds on the C5 position is described. The protocol employs commercially available N-fluorobenzenesulfonimide (NFSI) as the amination reagent and shows broad substrate scope, providing various 5-aminated quinolines in moderate to excellent yields under mild conditions. These reactions feature complete regioselectivity, operational simplicity, and high...