Triterpenoids and phenolics from the fruiting bodies of Inonotus hispidus and their activations of melanogenesis and tyrosinase

Two new 24-methyl lanostane triterpenoids, hispindic acids A and B (1 and 2), and a new phenolic compound, hispinine (7), along with nine known compounds (3–6, and 8–12), were isolated from the fruiting bodies of Inonotus hispidus. Their structures were elucidated based on the extensive analysis of spectroscopic data (NMR and HRMS). Hispindic acid A (1) possesses an unusual formyl group at C-30. Compounds 1, 3–4, and 8 showed stronger activate...