Original paper
Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling
Abstract
The comprehensive understanding of cellular signaling pathways remains a challenge due to multiple layers of regulation that may become evident only when the pathway is probed at different levels or critical nodes are eliminated. To discover regulatory mechanisms in canonical WNT signaling, we conducted a systematic forward genetic analysis through reporter-based screens in haploid human cells. Comparison of screens for negative, attenuating and...
Paper Details
Title
Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling
Published Date
Dec 20, 2016
Journal
Volume
5