Mechanical stress activates NMDA receptors in the absence of agonists
Abstract
While studying the physiological response of primary rat astrocytes to fluid shear stress in a model of traumatic brain injury (TBI), we found that shear stress induced Ca 2+ entry. The influx was inhibited by MK-801, a specific pore blocker of N-Methyl-D-aspartic acid receptor (NMDAR) channels, and this occurred in the absence of agonists. Other NMDA open channel blockers ketamine and memantine showed a similar effect. The competitive glutamate...
Paper Details
Title
Mechanical stress activates NMDA receptors in the absence of agonists
Published Date
Jan 3, 2017
Journal
Volume
7
Issue
1
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