Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure
Abstract
Chronic heart failure (HF) is associated with altered signal transduction via β-adrenoceptors and G proteins and with reduced cAMP formation. Nucleoside diphosphate kinases (NDPKs) are enriched at the plasma membrane of patients with end-stage HF, but the functional consequences of this are largely unknown, particularly for NDPK-C. Here, we investigated the potential role of NDPK-C in cardiac cAMP formation and contractility.Real-time polymerase...
Paper Details
Title
Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure
Published Date
Feb 28, 2017
Journal
Volume
135
Issue
9
Pages
881 - 897
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