PGI2 Controls Pulmonary NK Cells That Prevent Airway Sensitization to House Dust Mite Allergen

Volume: 198, Issue: 1, Pages: 461 - 471
Published: Jan 1, 2017
Abstract
In allergic asthma, inhalation of airborne allergens such as the house dust mite (HDM) effectively activates both innate and adaptive immunity in the lung mucosa. To determine the role of the eicosanoid PGI2 and its receptor IP during allergic airway sensitization, HDM responses in mice lacking a functional IP receptor (i.e., PGI2 IP receptor–deficient [IP−/−]) were compared with wild type (WT) mice. Surprisingly, IP−/− mice had increased...
Paper Details
Title
PGI2 Controls Pulmonary NK Cells That Prevent Airway Sensitization to House Dust Mite Allergen
Published Date
Jan 1, 2017
Volume
198
Issue
1
Pages
461 - 471
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