Human leukocyte antigen and idiosyncratic adverse drug reactions

Volume: 32, Issue: 1, Pages: 21 - 30
Published: Feb 1, 2017
Abstract
A clinical association between a specific human leukocyte antigen (HLA) allele and idiosyncratic adverse drug reactions (IADRs) is a strong indication that IADRs are mediated by the adaptive immune system. For example, it is well-established that HLA-B*15:02 and HLA-B*57:01 are associated with carbamazepine-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) and abacavir-induced hypersensitivity/flucloxacillin-induced liver...
Paper Details
Title
Human leukocyte antigen and idiosyncratic adverse drug reactions
Published Date
Feb 1, 2017
Volume
32
Issue
1
Pages
21 - 30
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