TRPV4 and activation of airway sensory nerves: The role of ATP
Published: Sep 1, 2015
Abstract
Activation of TRPV4 causes vagal nerve depolarisation, single airway fibre firing and reflex cough in the guinea pig (GP) through activating nodose derived Aδ fibres(Belvisi M.et al.AJRCCM:2013.A5265). Ca2+ signal and fibre firing demonstrated a short delay prior to activation, suggesting an indirect mechanism. Activation of TRPV4 possibly on the urothelium has been linked to ATP release and activation of P2X3 receptors on...
Paper Details
Title
TRPV4 and activation of airway sensory nerves: The role of ATP
Published Date
Sep 1, 2015
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