Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Volume: 13, Issue: 1, Pages: 81 - 90
Published: Nov 14, 2016
Abstract
Enigmatic lipid peroxidation products have been claimed as the proximate executioners of ferroptosis-a specialized death program triggered by insufficiency of glutathione peroxidase 4 (GPX4). Using quantitative redox lipidomics, reverse genetics, bioinformatics and systems biology, we discovered that ferroptosis involves a highly organized oxygenation center, wherein oxidation in endoplasmic-reticulum-associated compartments occurs on only one...
Paper Details
Title
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
Published Date
Nov 14, 2016
Volume
13
Issue
1
Pages
81 - 90
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