Immunogenic cell death in cancer and infectious disease

Published on Feb 1, 2017in Nature Reviews Immunology40.358
· DOI :10.1038/NRI.2016.107
Lorenzo Galluzzi127
Estimated H-index: 127
,
Aitziber Buqué23
Estimated H-index: 23
+ 2 AuthorsGuido Kroemer254
Estimated H-index: 254
Sources
Abstract
Initiation of an adaptive immune response depends on the detection of both antigenic epitopes and adjuvant signals. Infectious pathogens and cancer cells often avoid immune detection by limiting the release of danger signals from dying cells. When is cell death immunogenic and what are the pathophysiological implications of this process?
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