Determinants and prognostic implications of the negative diastolic pulmonary pressure gradient in patients with pulmonary hypertension due to left heart disease

Aims The diastolic pulmonary pressure gradient ( DPG ) has recently been introduced as a specific marker of combined pre‐capillary pulmonary hypertension (Cpc‐ PH ) in left heart disease ( LHD ). However, its diagnostic and prognostic superiority compared with traditional haemodynamic indices has been challenged lately. Current recommendations explicitly denote that in the normal heart, DPG values are greater than zero, with DPG ≥7 mmHg...