Co-delivery of doxorubicin and quercetin via mPEG–PLGA copolymer assembly for synergistic anti-tumor efficacy and reducing cardio-toxicity

Quercetin (Que) is a natural multifunctional bioflavonoid, and has shown great potential for reducing adverse side effects and enhancing anti-tumor efficacy of chemotherapeutic drugs. However, its clinical application is limited due to very low solubility and structural instability in physiological systems. Herein, we co-delivered hydrophobic quercetin and hydrophilic doxorubicin (Dox) by developing a biocompatible nanocarrier comprising of an...