Inflammaging and ‘Garb-aging’

Human aging is characterized by a state of chronic, low-grade, sterile inflammation (inflammaging), the causes of which are poorly understood. A possible cause of inflammaging is the continuous stimulation of macrophages by molecular garbage whose generation–disposal balance becomes impaired with age. Misplaced self-molecules can be sensed by macrophage receptors and contribute to inflammaging by activating the inflammasome. Self-molecules...