Original paper
Activation of the ATR kinase by the RPA-binding protein ETAA1
Abstract
Activation of the ATR kinase following perturbations to DNA replication relies on a complex mechanism involving ATR recruitment to RPA-coated single-stranded DNA via its binding partner ATRIP and stimulation of ATR kinase activity by TopBP1. Here, we discovered an independent ATR activation pathway in vertebrates, mediated by the uncharacterized protein ETAA1 (Ewing’s tumour-associated antigen 1). Human ETAA1 accumulates at DNA damage sites via...
Paper Details
Title
Activation of the ATR kinase by the RPA-binding protein ETAA1
Published Date
Oct 10, 2016
Journal
Volume
18
Issue
11
Pages
1196 - 1207