Metabolite and Microbiome Interplay in Cancer Immunotherapy

The role of the host microbiome has come to the forefront as a potential modulator of cancer metabolism and could be a future target for precision medicine. A recent study revealed that in colon cancer, bacteria form polysaccharide matrices called biofilms at a high frequency in the proximal colon. Comprehensive untargeted and stable isotope–assisted metabolomic analysis revealed that the bacteria utilize polyamine metabolites produced from...