Original paper
Calvarial Defect Healing Induced by Small Molecule Smoothened Agonist
Abstract
Hedgehog (Hh) signaling positively regulates both endochondral and intramembranous ossification. Use of small molecules for tissue engineering applications poses several advantages. In this study, we examined whether use of an acellular scaffold treated with the small molecule Smoothened agonist (SAG) could aid in critical-size mouse calvarial defect repair. First, we verified the pro-osteogenic effect of SAG in vitro, using primary neonatal...
Paper Details
Title
Calvarial Defect Healing Induced by Small Molecule Smoothened Agonist
Published Date
Dec 1, 2016
Journal
Volume
22
Issue
23-24
Pages
1357 - 1366
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History