Gene

Cell biology

Biotechnology

Biology

Mesenchymal stem cell

Materials science

Stem cell

Biochemistry

Biomaterial

In vivo

Nanotechnology

In vitro

Chemistry

Cell

Biophysics

Phenotype

Advanced Healthcare Materials

Material-induced cell aggregation drives a proangiogenic expression profile. Copolymer substrates containing cell-repellent and cell-adhesive domains force the aggregation of human mesenchymal stem cells, which results in enhanced tubulogenesis in vitro and stabilization of vasculature in vivo. These findings can be used to design instructive biomaterial scaffolds for clinical use.

Copolymer-Mediated Cell Aggregation Promotes a Proangiogenic Stem Cell Phenotype In Vitro and In Vivo