Red-shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina.
Abstract
Targeting the photosensitive ion channel channelrhodopsin-2 (ChR2) to the retinal circuitry downstream of photoreceptors holds promise in treating vision loss caused by retinal degeneration. However, the high intensity of blue light necessary to activate channelrhodopsin-2 exceeds the safety threshold of retinal illumination because of its strong potential to induce photochemical damage. In contrast, the damage potential of red-shifted light is...
Paper Details
Title
Red-shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina.
Published Date
Nov 1, 2016
Journal
Volume
8
Issue
11
Pages
1248 - 1264
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Notes
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