ITF promotes migration of intestinal epithelial cells through crosstalk between the ERK and JAK/STAT3 pathways

Intestinal trefoil factor (ITF), a member of the trefoil factor family, is a “Super-protective factor” for intestinal mucosal protection. This study was designed to explore the mechanism by which ITF promotes intestinal epithelial cell migration. Intestinal epithelial cells were treated with the human ITF (hITF). Phospho-ERK, phospho-STAT3 Tyr 705 , and phospho-STAT3 Ser 727 levels were detected at different time points by western blot. To...