Original paper
Cell-contact-dependent activation of CD4+T cells by adhesion molecules on synovial fibroblasts
Abstract
Objective: To determine how cell–cell contact with synovial fibroblasts (SF) influence on the proliferation and cytokine production of CD4+ T cells. Methods: Naïve CD4+ T cells were cultured with SF from rheumatoid arthritis patients, stimulated by anti-CD3/28 antibody, and CD4+ T cell proliferation and IFN-γ/IL-17 production were analyzed. To study the role of adhesion molecules, cell contact was blocked by transwell plate or anti-intracellular...
Paper Details
Title
Cell-contact-dependent activation of CD4+T cells by adhesion molecules on synovial fibroblasts
Published Date
Sep 13, 2016
Journal
Volume
27
Issue
3
Pages
448 - 456
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Notes
History