New acetylenic derivatives of betulin and betulone, synthesis and cytotoxic activity
Abstract
Betulin 1 and its semisynthetic derivatives exhibit a cytotoxic activity toward various cancer cell lines. These compounds are a promising and potential anticancer candidates. A series of betulin derivatives was prepared and tested for the antiproliferative activity in vitro against T47D breast cancer, CCRF/CEM leukemia, HL-60 promyelocytic leukemia, SW707 colorectal, murine P388 leukemia, as well as BALB3T3 normal fibroblasts cell lines....
Paper Details
Title
New acetylenic derivatives of betulin and betulone, synthesis and cytotoxic activity
Published Date
Sep 1, 2016
Journal
Volume
26
Issue
1
Pages
1 - 8
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