Synthesis, antiamoebic and molecular docking studies of furan-thiazolidinone hybrids
Abstract
In continuation of our previous work, a series of furan-thiazolidinone hybrids was prepared by Knoevenagel condensation of 3-(furan-2-ylmethyl)-2-(phenylimino)-1, 3-thiazolidin-4-one with different aryl aldehydes in presence of strong base. Some members of the series exhibited remarkable antiamoebic activity and cell viability. Three compounds (3, 6 and 11) showed excellent binding energy for Entamoeba histolytica O-acetyle-l-serine...
Paper Details
Title
Synthesis, antiamoebic and molecular docking studies of furan-thiazolidinone hybrids
Published Date
Nov 1, 2016
Volume
124
Pages
393 - 406
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