A mixed finite element method for modeling the fluid exchange between microcirculation and tissue interstitium

Thanks to dimensional (or topological) model reduction techniques, small inclusions in a three-dimensional (3D) continuum can be described as one-dimensional (1D) concentrated sources, in order to reduce the computational cost of simulations. However, concentrated sources lead to singular solutions that still require computationally expensive graded meshes to guarantee accurate approximation. The main computational barrier consists in the...