To investigate retinal displacement in the macula after surgical closure of idiopathic macular hole and to identify factors correlated with displacement.
This retrospective multicenter study included 73 eyes of 73 patients having idiopathic macular hole. A custom program was developed to compare the position of the retinal vessels in the macula between preoperative and postoperative photographs. En face images of a 6 mm × 6 mm optical coherence tomography volume scans were registered to calculate the scale. A grid comprising 16 sectors in 2 rings (inner; 2–4 mm and outer; 4–6 mm) was superimposed. The displacement of the retinal vessels was measured as a vector value by comparing the location of the retinal vessels in each sector. The correlation between displacement and various clinical parameters was analyzed.
The average displacement was 57.2 μm at an angle of −3.3° (nasal and slightly inferior). Displacement was larger in the inner ring (79.2 μm) than in the outer ring (35.3 μm, P < 0.001), and larger in the temporal sectors than in the corresponding nasal sectors (P ≤ 0.008). Inferior and superior displacement was noted in the superior and inferior sectors, respectively. Multiple regression analysis revealed that basal horizontal macular hole diameter and size of internal limiting membrane removal were independent factors of displacement.
The macula was displaced centripetally, nasally, and slightly inferiorly after surgical closure of idiopathic macular hole. Hole closure, contraction of the nerve fiber layer, and gravity are the suggested mechanisms of macular displacement caused by internal limiting membrane peeling.
Purpose To examine the retinal displacement following successful macular hole (MH) surgery with internal limiting membrane (ILM) peeling and gas tamponade, and to determine the correlation between the extent of displacement and the basal MH size. Design Retrospective, interventional, observational case series. Methods The medical records of consecutive patients with an idiopathic MH that had undergone vitrectomy with ILM peeling and gas tamponade were studied. The distances between the optic dis...
RESULTS. A DONFL appearance was found in 31 (66.0%) eyes on color fundus photography. The postoperative best-corrected visual acuity and its improvements were not significantly different between eyes with and without this appearance. The SD-OCT images showed small inner retinal defects corresponding to each arcuate stria in all eyes with the DONFL appearance. Of these eyes, 25 (80.6%) included inner retinal defects extending beyond the retinal nerve fiber layer (RNFL) into the ganglion cell laye...
PURPOSE: To investigate the papillofoveal distance and its association with retinal thickness on optical coherence tomography (OCT) images after vitrectomy for diabetic macular edema (DME). METHODS: In this retrospective case series, 72 eyes of 57 consecutive patients who underwent vitrectomy for DME were included. Retinal images dissecting the fovea horizontally were obtained using OCT before and after vitrectomy. After identification of the disc margin and the presumed foveal center, the papil...
#1Jae Hui Kim(SMC: Samsung Medical Center)H-Index: 7
#2Se Woong Kang(SMC: Samsung Medical Center)H-Index: 25
Last. Hyo Shin Ha(SMC: Samsung Medical Center)H-Index: 6
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Purpose To evaluate the elongation profile of foveal tissue after macular hole (MH) surgery and to investigate its impact on visual function. Design Prospective, interventional case series. Participants Thirty-one eyes from 31 patients who underwent surgery for an MH less than 400 μm in diameter. Methods The distance between the parafoveal edge of the outer plexiform layer (OPL) was defined as the inter-OPL distance and measured on the basis of optical coherence tomography images at the first po...
#1Cecilia Conde(CONICET: National Scientific and Technical Research Council)H-Index: 15
#2Alfredo Cáceres(CONICET: National Scientific and Technical Research Council)H-Index: 59
Microtubules are key determinants of neuronal polarity, which provides the basis of unidirectional signal transmission in the mature nervous system. This Review focuses on the regulation of microtubule assembly, organization and dynamics in developing axons and dendrites.
Selective indocyanine green (ICG) staining of the macula has recently become popular in internal limiting membrane (ILM) peeling allowing a better distinction of the ILM from the underlying retina. C
Purpose To evaluate the effect of internal limiting membrane (ILM) peeling and other variables in hole closure and functional success rate after idiopathic macular hole surgery. Design Retrospective, multicenter, observational study. Methods The records of 1627 patients operated on for idiopathic macular hole were collected retrospectively from 28 surgeons. All patients underwent a single pars plana vitrectomy and were divided into 2 groups: with and without ILM peeling. Preoperative, intraopera...
Last. Ji Eun Lee(PNU: Pusan National University)H-Index: 19
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Purpose To investigate the correlation between postoperative metamorphopsia and macular deformation after macular hole (MH) surgery. Methods This study included 28 eyes of 28 patients who underwent vitrectomy and internal limiting membrane (ILM) removal for idiopathic MH. The retinal vasculatures were compared between preoperative and postoperative photographs, and postoperative deformation of the macula was assessed as deformation of the square grid. The displacement of each node was measured, ...
Last. Stanislao Rizzo(CUA: The Catholic University of America)H-Index: 4
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PURPOSE To determinate the efficacy of the human amniotic membrane plugs with sulfur hexafluoride versus human amniotic membrane plug with air as endotamponade to treat macular holes that failed to close after vitrectomy plus internal limiting membrane peeling. We focused on multimodal imaging to evaluate pre-operative features and post-operative changes. MATERIALS AND METHODS Prospective interventional comparative study. Twenty eyes of 20 patients affected by macular hole that failed to close w...
BACKGROUND As a novel high magnification module (HMM) combining with OCT (OCT-HMM) is able to detect the microstructure of retina, we apply it to explore the ultrastructure of the macula after closure of the idiopathic macular hole (IMH) by surgery. METHODS This is an observational case series study in which patients with full-thickness IMHs who had undergone successful macular closure by vitrectomy and internal limiting membrane peeling and healthy subjects were recruited. After comprehensive o...
The failed macular hole is a full-thickness defect involving the fovea that fails to close despite 1 or more surgeries. While many surgical options have been proposed to manage it, none of these guarantee complete anatomical success and satisfactory visual recovery. We report postoperative outcomes on 36 patients affected by failed macular hole, treated with a human amniotic membrane plug transplant. Follow-ups were performed with a standard ophthalmological examination and with advanced multimo...
Purpose To describe the surgical outcomes of macular holes (MHs) by inserting a human amniotic membrane (hAM) plug. Methods In this retrospective, interventional, comparative case series, 10 patients who had undergone hAM plugging for a MH were included in the study. Seven patients had idiopathic full-thickness MHs, 1 patient had traumatic MH, and 1 patient each had a MH-induced retinal detachment and combined retinal detachment. The control group included 10 cases with similar configuration and...
It has been reported that the macular region of the retina is displaced after vitrectomy with internal limiting membrane (ILM) peeling in eyes with macular hole (MH), but the displacements of the deeper layers of the eye, e.g. RPE and choroid are unclear following the surgery. We used optical coherence tomography (OCT) and OCT angiography (OCTA) to obtain 3 mm × 3 mm en face images before, and 2, 4, and 8 weeks following the vitrectomy with internal limiting membrane (ILM) peeling from 22 eyes o...
BACKGROUND AND OBJECTIVE: To investigate the displacement of foveal retinal layers in surgically closed macular holes (MHs) after removal of the internal limiting membrane (ILM). PATIENTS AND METHODS: Medical records of 26 consecutive patients who underwent vitrectomy and removal of the ILM for idiopathic MH were retrospectively reviewed. En face optical coherence tomography images were exported at the level of the choroid, ellipsoid zone (EZ), and inner plexiform layer (IPL) at baseline and at ...
Last. June-Gone Kim(UOU: University of Ulsan)H-Index: 19
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Aims To investigate the structural changes of the superficial capillary plexuses (SCP) and deep capillary plexuses (DCP) using optical coherence tomography (OCT) angiography (OCTA) in patients with idiopathic macular hole (MH) after surgery, determine the factors related to changes of macular capillary plexuses and evaluate its association with postoperative visual outcomes. Methods Thirty-three patients with unilateral MH who were followed for ≥6 months after surgery were included. Ophthalmolog...
BACKGROUND AND OBJECTIVE: To analyze the foveal avascular zone (FAZ) area in superficial and deep retinal layers in patients with macular hole (MH) before and after surgery. PATIENTS AND METHODS: The authors studied 14 patients with unilateral MH. They examined a 3 mm × 3 mm area at the fovea before and 6 months after surgery using spectral-domain optical coherence tomography angiography. RESULTS: In eyes affected by MH, the mean preoperative superficial FAZ (0.45 ± 0.09 mm2) and deep FAZ (0.79 ...