Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis.

Volume: 113, Issue: 34, Pages: 201603244
Published: Aug 23, 2016
Abstract
Ferroptosis is form of regulated nonapoptotic cell death that is involved in diverse disease contexts. Small molecules that inhibit glutathione peroxidase 4 (GPX4), a phospholipid peroxidase, cause lethal accumulation of lipid peroxides and induce ferroptotic cell death. Although ferroptosis has been suggested to involve accumulation of reactive oxygen species (ROS) in lipid environments, the mediators and substrates of ROS generation and the...
Paper Details
Title
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis.
Published Date
Aug 23, 2016
Volume
113
Issue
34
Pages
201603244
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