Discovery of prostate specific antigen pattern to predict castration resistant prostate cancer of androgen deprivation therapy

Prostate specific antigen (PSA) is an important biomarker to monitor the response to the treatment, but has not been fully utilized as a whole sequence. We used a longitudinal biomarker PSA to discover a new prognostic pattern that predicts castration-resistant prostate cancer (CRPC) after androgen deprivation therapy. We transformed the longitudinal PSA into a discrete sequence, used frequent sequential pattern mining to find candidate patterns...