Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells

Volume: 126, Issue: 9, Pages: 3363 - 3376
Published: Aug 2, 2016
Abstract
T cells expressing antigen-specific chimeric antigen receptors (CARs) improve outcomes for CD19-expressing B cell malignancies. We evaluated a human application of T cells that were genetically modified using the Sleeping Beauty (SB) transposon/transposase system to express a CD19-specific CAR.T cells were genetically modified using DNA plasmids from the SB platform to stably express a second-generation CD19-specific CAR and selectively...
Paper Details
Title
Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells
Published Date
Aug 2, 2016
Volume
126
Issue
9
Pages
3363 - 3376
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