Dexamethasone-induced muscular atrophy is mediated by functional expression of connexin-based hemichannels
Volume: 1862, Issue: 10, Pages: 1891 - 1899
Published: Oct 1, 2016
Abstract
Long-term treatment with high glucocorticoid doses induces skeletal muscle atrophy. However, the molecular mechanism of such atrophy remains unclear. We evaluated the possible involvement of connexin-based hemichannels (Cx HCs) in muscle atrophy induced by dexamethasone (DEX), a synthetic glucocorticoid, on control (Cx43(fl/fl)Cx45(fl/fl)) and Cx43/Cx45 expression-deficient (Cx43(fl/fl)Cx45(fl/fl):Myo-Cre) skeletal myofibers. Myofibers of...
Paper Details
Title
Dexamethasone-induced muscular atrophy is mediated by functional expression of connexin-based hemichannels
Published Date
Oct 1, 2016
Volume
1862
Issue
10
Pages
1891 - 1899
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