Review paper
Novel Applications of Tetrazoles Derived from the TMSN3-Ugi Reaction
Published: Jan 1, 2016
Abstract
The distinguished properties of tetrazole moiety make it possible to be employed as bioisosteric substituent of carboxylic acid in developing biological active substances. Tetrazole possesses several advantages over carboxylic acids with respect to many aspects including metabolic stability, electronic distribution, hydrogen bonding, and lipophilicity. These advantages facilitate the interactions between ligands and receptors, and potentially...
Paper Details
Title
Novel Applications of Tetrazoles Derived from the TMSN3-Ugi Reaction
Published Date
Jan 1, 2016
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