Angiotensin type 1a receptors in the paraventricular nucleus of the hypothalamus control cardiovascular reactivity and anxiety-like behavior in male mice

This study tested the hypothesis that deletion of angiotensin type 1a receptors (AT 1a ) from the paraventricular nucleus of hypothalamus (PVN) attenuates anxiety-like behavior, hypothalamic-pituitary-adrenal (HPA) axis activity, and cardiovascular reactivity. We used the Cre/LoxP system to generate male mice with AT 1a specifically deleted from the PVN. Deletion of the AT 1a from the PVN reduced anxiety-like behavior as indicated by increased...