Structure and function of the bacterial decapping enzyme NudC

Volume: 12, Issue: 9, Pages: 730 - 734
Published: Jul 18, 2016
Abstract
RNA capping and decapping are thought to be distinctive features of eukaryotes. The redox cofactor NAD was recently discovered to be attached to small regulatory RNAs in bacteria in a cap-like manner, and Nudix hydrolase NudC was found to act as a NAD-decapping enzyme in vitro and in vivo. Here, crystal structures of Escherichia coli NudC in complex with substrate NAD and with cleavage product NMN reveal the catalytic residues lining the binding...
Paper Details
Title
Structure and function of the bacterial decapping enzyme NudC
Published Date
Jul 18, 2016
Volume
12
Issue
9
Pages
730 - 734
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