Wogonin Inhibits Transforming Growth Factor β1–induced Extracellular Matrix Production via the p38/activator Protein 1 Signaling Pathway in Nasal Polyp–derived Fibroblasts

Wogonin has been shown to have antifibrotic and anti-inflammatory effects in the lower airway. The purpose of this study was to evaluate the effects of wogonin on transforming growth factor (TGF) β1-induced myofibroblast differentiation, extracellular matrix production, migration, and collagen contraction, and to determine the molecular mechanisms of wogonin in nasal polyp-derived fibroblasts (NPDF).NPDFs were isolated from nasal polyps from...