Abstract 2959: Peptide-linked indolino-benzodiazepine DNA-alkylating agents for use in antibody-drug conjugates (ADCs)

As part of our efforts to expand the available toolbox of cytotoxic payloads for use in antibody-drug conjugates (ADCs), we have recently described the development of the mono-imine-containing indolino-benzodiazepine dimer, IGN-P1 (Miller, et al., AACR 2014 #652). IGN-P1 was conjugated via a protease-cleavable peptidic L-alanine-L-alanine linker to a folate receptor α (FRα)-binding antibody, and an EGFR-binding antibody. The resulting ADCs...