Comparison between indocyanine green angiography and fluorescein angiography in normal cats

Published on Jul 1, 2017in Veterinary Ophthalmology1.105
· DOI :10.1111/VOP.12418
Miri Hayashi4
Estimated H-index: 4
(Rakuno Gakuen University),
Seiya Maehara8
Estimated H-index: 8
(Rakuno Gakuen University)
+ 3 AuthorsTetsuya Nakade13
Estimated H-index: 13
(Rakuno Gakuen University)
Sources
Abstract
Objective To study a new approach to indocyanine green (ICG) angiography for contrasting the ocular fundus in cats. Animals studied Six healthy laboratory cats. Procedures Fluorescein (FLUO) and ICG angiography were performed using an infrared-sensitive charged coupled device-equipped fundus camera on sedated cats. Results At 12.3 ± 3.4 s after ICG administration, the choroidal arteries could be seen extending radially from the optic disk. The choroidal veins became apparent at 16.2 ± 4.1 s alongside the choroidal arteries. Gradual fading of the choroidal vessels began 5.8 ± 1.5 min postdye administration and diffuse fluorescence of the fundus appeared. Diffuse fluorescence of the optic disk faded at about 18.8 ± 2.9 min. Mean arterial blood pressure at 1 and 3 min after ICG administration showed no significant change when compared to pre-administration (P > 0.05). However, 5 min (P = 0.054) and 10 min (P < 0.05) postadministration, a significant drop in blood pressure occurred. The time lapse between FLUO administration and its appearance in the ocular fundus was 15.7 ± 3.8 s. Retinal veins became apparent at 22.0 ± 3.6 s alongside retinal arteries. At 31.2 ± 4.1 s, full venous fluorescence was visualized throughout the entire fundus. Conclusions While FLUO angiography shows only the retinal vessels, ICG angiography enabled visualization of the choroidal vasculature. ICG angiography provides clear resolution while remaining reliable and simple; thus, a combination of ICG and FLUO angiography shows promise as a diagnostic aid for clinical evaluation of various chorioretinal diseases in cats.
📖 Papers frequently viewed together
120 Citations
26 Citations
2 Citations
References12
Newest
#1Shinsuke Wakaiki (Rakuno Gakuen University)H-Index: 6
#2Seiya Maehara (Rakuno Gakuen University)H-Index: 8
Last. Yasuharu Izumisawa (Rakuno Gakuen University)H-Index: 16
view all 9 authors...
In dogs, a variety of diseases of the retina and choroid have been reported, either separately or concomitantly; however, the canine choroid is difficult to evaluate by veterinary techniques currently available. Indocyanine green (ICG) angiography is widely used in human ophthalmology, but has not been investigated for use in canine ophthalmology. The aim of this study was to apply a new approach to ICG angiography and compare the resulting angiograms with fluorescein (FLUO) angiograms of the oc...
6 CitationsSource
#1Karin Ishikawa (Keio: Keio University)H-Index: 7
#2Tomoyo Funayama (Keio: Keio University)H-Index: 11
Last. Yukihiko Mashima (Keio: Keio University)H-Index: 46
view all 5 authors...
Purpose To determine whether genetic polymorphisms of the genes for oxidative stress and apoptosis cause the clinical variability in patients with Leber’s hereditary optic neuropathy (LHON).
14 CitationsSource
#1Shin Yoneya (Saitama Medical University)H-Index: 25
: One advantage of advanced computer technology is the high throughput with which the retinal and the choroidal circulation can be evaluated from new aspects. To study the choroidal circulation, we first reevaluated indocyanine green video angiography to improve the visualization of indocyanine green (ICG) images, then applied computer technology to analyze images obtained by an ICG video camera system. We also developed a new instrument to measure oxygen saturation levels in the fundus using sp...
5 Citations
#1Kiyoshi Kano (OCU: Osaka City University)H-Index: 5
#2Takeya Kohno (OCU: Osaka City University)H-Index: 12
Last. Kunihiko Shiraki (OCU: Osaka City University)H-Index: 17
view all 4 authors...
Abstract Purpose: The purpose of this study was to investigate the effects of rapid intravenous administration of a small bolus of indocyanine green (ICG) dye on early phase findings of ICG angiography. Methods: Rabbit eyes were used. Ten normal eyes, 5 eyes with occlusion of vortex veins, and 5 eyes with chorioretinal atrophy were examined by ICG angiography, and early-phase findings after a rapid injection of a small bolus of dye were compared with those obtained with an ordinary injection. Re...
3 CitationsSource
#1Naoko Matsuda (Kyoto University)H-Index: 4
#2Yuichiro Ogura (Kyoto University)H-Index: 42
Last. Yoshihito Honda (Kyoto University)H-Index: 67
view all 7 authors...
Purpose. To report a method to evaluate leukocyte dynamics in the choroidal circulation with indocyanine green (ICG) angiography. Methods. Nonpigmented and pigmented rats were administered ICG solution intravenously. The fundus image was obtained with a scanning laser ophthalmoscope and recorded on magnetic tapes at a video rate (30 frames/second). The images were analyzed with a personal computer-based image analysis system. Results. On ICG angiography, hyperfluorescent dots were seen moving al...
22 Citations
#1L. K. Cullen (Murdoch University)H-Index: 12
Medetomidine is a relatively new sedative analgesic in dogs and cats but some precautions are required when using it. It is a potent α2-adrenoceptor agonist and stimulates receptors centrally to produce dose-dependent sedation and analgesia and receptors centrally and peripherally to cause marked bradycardia and decrease the cardiac output. While hypotension occurs frequently, higher doses of the sedative can raise the blood pressure due to an affect on peripheral receptors. Slowing of the respi...
122 CitationsSource
#1L De SchaepdrijverH-Index: 6
#2Paul SimoensH-Index: 27
Last. Henri LauwersH-Index: 17
view all 3 authors...
7 Citations
#1N. SutohH-Index: 1
#2K. MuraokaH-Index: 1
Last. K. TakahashiH-Index: 1
view all 4 authors...
2 Citations
#1Peter Bischoff (Kantonsspital St. Gallen)H-Index: 8
#2Robert W. Flower (Johns Hopkins University)H-Index: 13
The choroidal circulation can be studied by an angiographic technique which utilizes near-infrared light wavelengths and a biocompatible dye, indocyanine green (CardiogreenR). Near-infrared light is less absorbed than visible light by the pigment epithelium and the macular xanthophyll, and indocyanine green (ICG) dye doesn't leak from the choriocapillaris as sodium fluorescein dye typically does. Due to the high rate of choroidal blood flow, a fundus camera adapted with special filters and a con...
144 CitationsSource
#2Bunch SeH-Index: 6
#3Baldwin BhH-Index: 21
Last. Tennant BcH-Index: 4
view all 4 authors...
: Plasma disappearances of sulfobromophthalein (BSP) and indocyanine green (ICG) given in single-dose IV injections to cats were measured. The BSP was given at a dose of 5 mg/kg of body weight; ICG was given at a dose of 1.5 mg/kg of body weight. The half-life, disappearance rate (percent per minute) and clearance (ml/min/kg) were determined during the initial phase of plasma dye elimination. The half-life for BSP was 2.2 +/- 0.7 minutes, and for ICG, 3.8 +/- 0.9 minutes. The disappearance rate ...
24 Citations
Cited By2
Newest
#1Gwang Myeong Noh (Kosin University)H-Index: 2
#2Jae Wan LimH-Index: 2
Last. Sang Joon Lee (Kosin University)H-Index: 11
view all 5 authors...
PURPOSE: We investigated structural changes in the retina by using optical coherence tomography (OCT) in a feline model of retinal degeneration using iodoacetic acid (IAA). METHODS: We examined 22 eyes of 11 felines over 2 years of age. The felines had fasted for 12 hours and were intravenously injected with IAA 20 mg/kg of body weight. OCT (Spectralis OCT) was performed at the point where the ends of the retinal vessels collected in the lateral direction from the optic nerve head and area centr...
Source
#1Ruyuan Liu (SYSU: Sun Yat-sen University)H-Index: 2
#2Jing Lu (SYSU: Sun Yat-sen University)H-Index: 4
Last. Lin Lu (SYSU: Sun Yat-sen University)H-Index: 14
view all 13 authors...
Purpose: We evaluate the effect of choroidal vessel density on the residual length of the ellipsoid zone (EZ) and visual function in patients with retinitis pigmentosa (RP) using optical coherence tomography angiography (OCTA). Methods: Fifty-three patients with RP (n = 101 eyes) and 53 normal participants (n = 76 eyes) were enrolled in this study. Patients with RP were assigned to three groups according to their best-corrected visual acuity (BCVA). All patients underwent ophthalmologic examinat...
6 CitationsSource