Tumor Necrosis Factor‐α Attenuates the Osteogenic Differentiation Capacity of Periodontal Ligament Stem Cells by Activating PERK Signaling

Volume: 87, Issue: 8
Published: Aug 1, 2016
Abstract
Background: Human periodontal ligament stem cells (PDLSCs) display efficient osteogenic differentiation capacity but fail to rescue bone breakdown associated with periodontitis. Endoplasmic reticulum (ER) stress and the unfolded protein response have recently been linked to inflammation and osteogenic differentiation. Therefore, the role of the double‐stranded RNA‐activated protein kinase (PKR)‐like ER kinase (PERK) pathway in the impaired...
Paper Details
Title
Tumor Necrosis Factor‐α Attenuates the Osteogenic Differentiation Capacity of Periodontal Ligament Stem Cells by Activating PERK Signaling
Published Date
Aug 1, 2016
Volume
87
Issue
8
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.