Review paper
High-throughput sequencing offers new insights into 5-hydroxymethylcytosine
Abstract
Chemical modifications of DNA comprise epigenetic mechanisms that contribute to the maintenance of cellular activities and memory. Although the function of 5-methylcytosine (5-mC) has been extensively studied, little is known about the function(s) of relatively rarer and underappreciated cytosine modifications including 5-hydroxymethylcytosine (5-hmC). The discovery that ten-eleven translocation (Tet) proteins mediate conversion of 5-mC to...
Paper Details
Title
High-throughput sequencing offers new insights into 5-hydroxymethylcytosine
Published Date
Jun 1, 2016
Journal
Volume
7
Issue
3
Pages
169 - 178
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