Global intron retention mediated gene regulation during CD4+T cell activation

Volume: 44, Issue: 14, Pages: 6817 - 6829
Published: Jul 1, 2016
Abstract
T cell activation is a well-established model for studying cellular responses to exogenous stimulation. Using strand-specific RNA-seq, we observed that intron retention is prevalent in polyadenylated transcripts in resting CD4(+) T cells and is significantly reduced upon T cell activation. Several lines of evidence suggest that intron-retained transcripts are less stable than fully spliced transcripts. Strikingly, the decrease in intron...
Paper Details
Title
Global intron retention mediated gene regulation during CD4+T cell activation
Published Date
Jul 1, 2016
Volume
44
Issue
14
Pages
6817 - 6829
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