Role of microRNAs in the regulation of normal T cell development and pathogenesis

Several cases of T cell Acute lymphoblastic leukemia (T-ALL), one of the neoplasms associated with T cells, arises from immature thymocytes corresponding to initial stages of maturation. Different T-ALL subtypes have chromosomal translocations between promoter elements of the genes of T cell receptors and oncogenic transcription factors. More recently, the deregulation of microRNAs, genes and transcription factors associated with normal T cell...