[The cloning and expression of apoptosis associated gene ANNEXIN A2 induced by p53 gene].

To identify the relationship between p53-dependent apoptosis associated genes and tumor metastasis.mRNA differential display (mRNA DD) was adopted for gene cloning after the different metastatic potential lung cancer cell lines were infected by Adv-p53 (a reconstructed adenovirus encoding wild type p53 gene). RT-PCR, Northern blot and Western blot assays were used to confirm the result from mRNA DD.After induction by p53 gene, the ANNEXIN A2...