[The effect of the compatibility of Radix Aconiti Laterlis and radix glycyrrhizae on pharmacokinatic of aconitine, mesaconitine and hypacmitine in rat plasma].

Published on Jun 1, 2011in Journal of Chinese medicinal materials
Hong Shen15
Estimated H-index: 15
Ling-Ying Zhu8
Estimated H-index: 8
+ 1 AuthorsJie Wu128
Estimated H-index: 128
Objective:To established an HPLC-MS assay to determine aconitine,mesaconitine and hypaconitine simultaneously in rat plasma and be used to investigate the pharmacokinetics of the three alkaloids.Methods:Three groups of rats were orally administered respectively with three decoctions including decoction of Radix Aconiti Laterlis,blend decoction of Radix Aconiti Laterlis and Radix Glycyrrhizae which decocted separately,decoction of Radix Aconiti Laterlis and Radix Glycyrrhizae which decocted together,the dosage of Radix Aconiti Laterlis was 1.5 g/kg.The contents of aconitine,mesaconitine and hypaconitine in rat plasma were detected using a liquid Chromatography-electrospray ionization/tandem mass spectrometry method.Pharmacokinetic parameters were estimated using DAS 2.0.Results:The pharmacokinetic parameters of the three compounds obtained showed that Cmax and AUC of aconitine,mesaconitine and hypaconitine were decreased.MRT銆乼1/2 were prolonged and there was no obviously change in Tmax when Radix Aconiti Lateralis was combined with Radix Glycyrrhizae.The effect of decoction which decocted together was more prominent than which decocted separately.Conclusion:There are obvious effects on pharmacokinetic of Aconitine,Mesaconitine and Hypaconitine in Rat Plasma when Radix Aconiti Laterlis is combined with Radix Glycyrrhizae.
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