Extended pelvic lymphadenectomy in patients with clinically localised prostate cancer: A prospective observational study.

Published on Sep 1, 2016in Actas Urologicas Espanolas0.994
· DOI :10.1016/J.ACUROE.2016.06.006
José Gustavo Ramos2
Estimated H-index: 2
(Pontifical Xavierian University),
Juan Ignacio Caicedo6
Estimated H-index: 6
(University of Los Andes)
+ 4 AuthorsMauricio Plata7
Estimated H-index: 7
(University of Los Andes)
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Abstract
Abstract Objective To determine the frequency of lymph node involvement in patients with clinically localized prostate adenocarcinoma who had radical prostatectomy and extended pelvic lymphadenectomy. Material and methods A prospective observational study was conducted on 137 patients with clinically localized prostate cancer of low, intermediate or high risk according to the D’Amico classification. All participants underwent radical prostatectomy plus extended pelvic lymphadenectomy in 3 reference centers in Bogota, Colombia, between 2013 and 2014. The following variables were assessed: age, prostate specific antigen levels, Gleason score of the biopsy, probability of lymph node involvement calculated with Partin tables and the histopathology result of the surgical specimen, with the definitive Gleason pattern and the total number of resected and involved lymph nodes per tumor, according to the territory of the dissection. Results A total of 2876 lymph nodes were extracted (an average of 20.99 lymph nodes per patient). There was lymph node involvement in 14 (10.22%) patients. The high-risk and intermediate-risk group presented lymph node metastases in 28.57% and 5.25%, respectively. There was no lymph node involvement in the low-risk group. Of the patients at risk of lymph node involvement (≥2% according to the Partin tables), 19.40% had lymph node metastases. Conclusion Lymph node involvement in our population is similar to that reported in the worldwide literature. Extended pelvic lymphadenectomy increased the probability of detecting lymph node metastases in our community.
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#2L. RegueroH-Index: 1
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Abstract Objective To analyze the correlation between pathological data found in radical prostatectomy and previously performed biopsy in patients at low risk prostate cancer. Material and methods A descriptive, cross-sectional study was conducted to assess the characteristics of radical prostatectomies performed in our center from January 2012 to November 2014. The inclusion criteria were patients with low-risk disease (cT1c–T2a, PSA ≤ 10 ng/ml and Gleason score ≤ 6). We excluded patients who h...
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Resumen Objetivo Analizar la correlacion entre los datos anatomopatologicos encontrados en prostatectomia radical y la biopsia previa realizada en pacientes con cancer de prostata de bajo riesgo. Material y metodos Se ha realizado un estudio descriptivo transversal para valorar las caracteristicas de las prostatectomias radicales realizadas en nuestro centro desde enero de 2012 a noviembre de 2014. Los criterios de inclusion fueron pacientes con enfermedad de bajo riesgo (cT1c-T2a, PSA ≤ 10 ng/m...
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Purpose: The 2011 NCCN (National Comprehensive Cancer Network) guidelines for prostate cancer recommend pelvic lymph node dissection at radical prostatectomy in all individuals with a nomogram predicted lymph node invasion probability of 2% or greater. We examined the ability of these guidelines to correctly predict lymph node invasion in patients treated with extended pelvic lymph node dissection.Materials and Methods: We examined 3,064 consecutive patients treated with radical prostatectomy an...
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