Extended pelvic lymphadenectomy in patients with clinically localised prostate cancer: A prospective observational study.

Published on Sep 1, 2016in Actas Urologicas Espanolas0.994
· DOI :10.1016/J.ACUROE.2016.06.006
José Gustavo Ramos2
Estimated H-index: 2
 (Pontifical Xavierian University), Juan Ignacio Caicedo6
Estimated H-index: 6
 (University of Los Andes)+ 4 AuthorsMauricio Plata7
Estimated H-index: 7
 (University of Los Andes)
Sources
Abstract
Abstract Objective To determine the frequency of lymph node involvement in patients with clinically localized prostate adenocarcinoma who had radical prostatectomy and extended pelvic lymphadenectomy. Material and methods A prospective observational study was conducted on 137 patients with clinically localized prostate cancer of low, intermediate or high risk according to the D’Amico classification. All participants underwent radical prostatectomy plus extended pelvic lymphadenectomy in 3 reference centers in Bogota, Colombia, between 2013 and 2014. The following variables were assessed: age, prostate specific antigen levels, Gleason score of the biopsy, probability of lymph node involvement calculated with Partin tables and the histopathology result of the surgical specimen, with the definitive Gleason pattern and the total number of resected and involved lymph nodes per tumor, according to the territory of the dissection. Results A total of 2876 lymph nodes were extracted (an average of 20.99 lymph nodes per patient). There was lymph node involvement in 14 (10.22%) patients. The high-risk and intermediate-risk group presented lymph node metastases in 28.57% and 5.25%, respectively. There was no lymph node involvement in the low-risk group. Of the patients at risk of lymph node involvement (≥2% according to the Partin tables), 19.40% had lymph node metastases. Conclusion Lymph node involvement in our population is similar to that reported in the worldwide literature. Extended pelvic lymphadenectomy increased the probability of detecting lymph node metastases in our community.
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References30
Newest
Mar 1, 2016·Actas Urologicas Espanolas0.99
#1A. GuijarroH-Index: 5
#2L. RegueroH-Index: 1
Last. Carlos LlorenteH-Index: 10
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Resumen Introduccion La linfadenectomia en el cancer de prostata (CP) es el procedimiento mas fiable para la deteccion de metastasis linfaticas. La extension optima de la misma aun es un tema en debate. Objetivo Analizar el rendimiento diagnostico y las complicaciones de la linfadenectomia ampliada (LFDNA) y limitada (LFDNL) en una serie de pacientes con CP de alto riesgo sometidos a prostatectomia radical (PR). Material y metodos Estudio retrospectivo de pacientes con CP de alto riesgo de D’Ami...
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Abstract Objective To analyze the correlation between pathological data found in radical prostatectomy and previously performed biopsy in patients at low risk prostate cancer. Material and methods A descriptive, cross-sectional study was conducted to assess the characteristics of radical prostatectomies performed in our center from January 2012 to November 2014. The inclusion criteria were patients with low-risk disease (cT1c–T2a, PSA ≤ 10 ng/ml and Gleason score ≤ 6). We excluded patients who h...
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Resumen Objetivo Analizar la correlacion entre los datos anatomopatologicos encontrados en prostatectomia radical y la biopsia previa realizada en pacientes con cancer de prostata de bajo riesgo. Material y metodos Se ha realizado un estudio descriptivo transversal para valorar las caracteristicas de las prostatectomias radicales realizadas en nuestro centro desde enero de 2012 a noviembre de 2014. Los criterios de inclusion fueron pacientes con enfermedad de bajo riesgo (cT1c-T2a, PSA ≤ 10 ng/m...
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Feb 1, 2015·The Prostate4.10
#1J.B. PinaquyH-Index: 3
#2Henri de Clermont-Galleran (University of Bordeaux)H-Index: 2
Last. Philippe Fernandez (University of Bordeaux)H-Index: 10
view all 8 authors...
BACKGROUND Accurate staging is important before surgical decision in patients with high-risk prostate cancer (PCa). The purpose of this study was to prospectively compare the diagnostic performance of 18F-FCholine and MRI with diffusion weighted imaging (DWIMRI) for local and regional lymph node (LN) staging before radical prostatectomy (RP) with extended pelvic lymphadenectomy (PLND). METHODS We identified 47 patients who underwent 18F-FCholine and DWIMRI followed by surgical treatment (either ...
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Jun 1, 2014·Actas Urologicas Espanolas0.99
#1F. Lista (UEM: European University of Madrid)H-Index: 9
#2H. Gimbernat (UEM: European University of Madrid)H-Index: 10
Last. Javier C. Angulo (UEM: European University of Madrid)H-Index: 35
view all 6 authors...
Resumen Introduccion La correcta evaluacion de la extension extracapsular (EEC), la invasion de las vesiculas seminales y de los ganglios linfaticos regionales es necesaria para planificar el tratamiento a seguir en el cancer de prostata localizado. Se define un modelo que evalua el riesgo de EEC en el especimen considerando los hallazgos clinicos, histopatologicos y de imagen. Material y metodos Estudio prospectivo en 85 pacientes con cancer de prostata tratados mediante prostatectomia radical....
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Jan 1, 2014·European Urology20.10
#1Axel Heidenreich (RWTH Aachen University)H-Index: 73
#2Patrick J. BastianH-Index: 51
Last. Nicolas MottetH-Index: 39
view all 11 authors...
Abstract Context The most recent summary of the European Association of Urology (EAU) guidelines on prostate cancer (PCa) was published in 2011. Objective To present a summary of the 2013 version of the EAU guidelines on screening, diagnosis, and local treatment with curative intent of clinically organ-confined PCa. Evidence acquisition A literature review of the new data emerging from 2011 to 2013 has been performed by the EAU PCa guideline group. The guidelines have been updated, and levels of...
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Dec 1, 2013·The Journal of Urology7.45
#1In Gab Jeong (UOU: University of Ulsan)H-Index: 27
#2Ju Hyun Lim (UOU: University of Ulsan)H-Index: 6
Last. Choung-Soo Kim (UOU: University of Ulsan)H-Index: 30
view all 10 authors...
Purpose: We investigated the incremental value of magnetic resonance imaging in addition to clinical variables for predicting pathological outcomes and disease recurrence in patients with clinically high risk prostate cancer.Materials and Methods: A total of 922 consecutive patients with clinically high risk prostate cancer underwent magnetic resonance imaging before radical prostatectomy. We created multivariate logistic regression and Cox proportional hazards models with clinical variables onl...
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Jan 1, 2013·BJUI23.06
#2Zhaoyang Feng (Johns Hopkins University)H-Index: 1
#3Brian M. Lin (Johns Hopkins University)H-Index: 24
Last. Alan W. Partin (Johns Hopkins University)H-Index: 125
view all 10 authors...
Objective To update the 2007 Partin tables in a contemporary patient population. Patients and Methods The study population consisted of 5,629 consecutive men who underwent RP and staging lymphadenectomy at the Johns Hopkins Hospital between January 1, 2006 and July 30, 2011 and met inclusion criteria. Polychotomous logistic regression analysis was used to predict the probability of each pathologic stage category: organ-confined disease (OC), extraprostatic extension (EPE), seminal vesicle involv...
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Aug 1, 2012·The Journal of Urology7.45
#1Firas Abdollah (UniSR: Vita-Salute San Raffaele University)H-Index: 64
#2Maxine Sun (UdeM: Université de Montréal)H-Index: 78
Last. Alberto Briganti (UniSR: Vita-Salute San Raffaele University)H-Index: 99
view all 12 authors...
Purpose: The 2011 NCCN (National Comprehensive Cancer Network) guidelines for prostate cancer recommend pelvic lymph node dissection at radical prostatectomy in all individuals with a nomogram predicted lymph node invasion probability of 2% or greater. We examined the ability of these guidelines to correctly predict lymph node invasion in patients treated with extended pelvic lymph node dissection.Materials and Methods: We examined 3,064 consecutive patients treated with radical prostatectomy an...
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Jul 17, 2012·Annals of Internal Medicine25.39
#1Virginia A. Moyer (University of Texas Health Science Center at Houston)H-Index: 65
Recommendation: The USPSTF recommends against PSA-based screening for prostate cancer (grade D recommendation). This recommendation applies to men in the general U.S. population, regardless of age. This recommendation does not include the use of the PSA test for surveillance after diagnosis or treatment of prostate cancer; the use of the PSA test for this indication is outside the scope of the USPSTF.
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Cited By1
Newest
#1Julián Chavarriaga (Pontifical Xavierian University)H-Index: 3
#2Catalina Barco-CastilloH-Index: 2
Last. Juan Ignacio CaicedoH-Index: 6
view all 8 authors...
Introduction Prediction of lymph node involvement (LNI) is of paramount importance for patients with prostate cancer (PCa) undergoing radical prostatectomy (RP). Multiple statistical models predicting LNI have been developed to support clinical decision-making regarding the need of extended pelvic lymph node dissection (ePLND). Our aim is to evaluate the prediction ability of the best-performing prediction tools for LNI in PCa in a Latin-American population. Methods Clinicopathological data of 8...
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1
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