Challenge of the supercritical antisolvent technique SAS to prepare cocrystal-pure powders of naproxen-nicotinamide

Crystallization assisted by supercritical CO2 has been long ago developed for micronization purposes, but its application to fabricate cocrystals is in its infancy. In this work, the cocrystallization of naproxen and nicotinamide was investigated using CO2 as an antisolvent. In the so-called SAS technique (Supercritical AntiSolvent) a solution of the species dissolved in acetone was injected into a continuous flow of CO2. The conditions of...