High quality three‐dimensional gagCEST imaging of in vivo human knee cartilage at 7 Tesla

Purpose To develop a new faster and higher quality three‐dimensional (3D) gagCEST MRI technique for reliable quantification of glycosaminoglycan (GAG) present in the human knee cartilages. Methods A new magnetization‐prepared 3D gradient echo‐based MRI pulse sequence has been designed to obtain the B 0 inhomogeneity, B 1 inhomogeneity, and CEST Z‐spectra images. Results The gagCEST values of different compartments of knee cartilage are...