RRLC- TOF/MS in identification of plasma constituents and metabolites of epimedium in rats after intragastric administration

Objective To identify the constituents and metabolites of epimedium in rat plasma by rapid-resolution liquid chromatography-time of flight mass spectrometry(RRLC-TOF/MS)after intragastric administration,so as to explore the active ingredients and metabolites of epimediumin vivo.Methods The separation was performed on a SHISEIDO MG C18 reverse phase column(3.0 mm×100 mm,3μm).The mobile phase consisted of water containing 0.1% formic acid and...