Abnormal Corneal Lesions Induced by Trastuzumab Emtansine

Purpose: To report a case of atypical corneal lesions presumably induced by trastuzumab emtansine, an antibody–drug conjugate that is designed to selectively deliver cytotoxic agents to human epidermal growth factor receptor 2 (HER2)–positive breast cancer cells. Case: A 64-year-old Japanese woman developed bilateral corneal epithelial abnormalities that originated from the limbus. The corneal lesions covered the superior area in the right eye...