Original paper
HUWE 1 interacts with PCNA to alleviate replication stress
Abstract
Defects in DNA replication, DNA damage response, and DNA repair compromise genomic stability and promote cancer development. In particular, unrepaired DNA lesions can arrest the progression of the DNA replication machinery during S‐phase, causing replication stress, mutations, and DNA breaks. HUWE 1 is a HECT ‐type ubiquitin ligase that targets proteins involved in cell fate, survival, and differentiation. Here, we report that HUWE 1 is...
Paper Details
Title
Published Date
May 4, 2016
Journal
Volume
17
Issue
6
Pages
874 - 886
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Notes
History